TRIM23

Across TCGA patient cohorts, TRIM23 mutation is significantly associated with the RNA expression of many other genes, with 2,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM23-associated genes across cancer lineages are SNX18P23, MIR3908, and HMGB1P7. Each is linked with TRIM23 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM23-to-partner and partner-to-TRIM23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX18P23 grouped by TRIM23-low versus TRIM23-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM23→partner) and Y-score (partner→TRIM23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNX18P23 →	+0.170	+5.069	<.001	.008	3	3
SKCM	MIR3908 →	+0.234	+4.385	<.001	.008	3	3
READ	HMGB1P7 →	+0.131	+4.202	.001	.008	3	2
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	2
READ	MIR6870 →	+0.822	+4.280	<.001	.007	3	2
LIHC	OR10W1 →	+0.094	+6.008	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,900 associations by consensus.

SNX18P23 by TRIM23 expression — HNSC

Explore this box plot interactively →