TRIM23

Across TCGA patient cohorts, TRIM23 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM23-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and JNK2. Each is linked with TRIM23 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM23-to-partner and partner-to-TRIM23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TRIM23-low versus TRIM23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM23→partner) and Y-score (partner→TRIM23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.436	+1.682	.015	.006	3	4
UCEC	INPP4B →	-0.237	-1.584	.015	.015	3	2
UCEC	JNK2 →	+0.173	+1.530	.004	.004	3	2
UCEC	STAT3_pY705 →	-0.328	-1.530	<.001	.004	3	2
UCEC	Cyclin-B1 →	+0.513	+2.000	.002	.009	3	2
UCEC	EGFR_pY1068 →	-0.220	-1.321	.003	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by TRIM23 expression — UCEC

Explore this box plot interactively →