TRIM22

Across TCGA patient cohorts, TRIM22 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM22-associated genes across cancer lineages are eEF2, eIF4E, and ERK2. Each is linked with TRIM22 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM22-to-partner and partner-to-TRIM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TRIM22-low versus TRIM22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM22→partner) and Y-score (partner→TRIM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.241	+2.459	.044	.018	3	2
UCEC	eIF4E →	+0.141	+1.874	.045	.002	3	2
UCEC	ERK2 →	+0.224	+2.502	<.001	.001	3	2
UCEC	MEK1 →	+0.249	+1.321	.042	.029	3	2
UCEC	mTOR_pS2448 →	-0.125	-1.986	.012	.029	3	2
UCEC	Shc_pY317 →	-0.115	-1.321	.023	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eEF2 by TRIM22 expression — UCEC

Explore this box plot interactively →