TRIM22

Across TCGA cell cohorts, TRIM22 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,518 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TRIM22-associated GO terms across cancer lineages are Defense response to virus, Innate immune response-activating signaling pathway, and CD8-positive, alpha-beta T cell activation. Each is linked with TRIM22 in more than 14 cancer types. Because this analysis shows association rather than direction, both TRIM22-to-partner and partner-to-TRIM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Defense response to virus grouped by TRIM22-low versus TRIM22-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM22→partner) and Y-score (partner→TRIM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.102	+3.253	<.001	<.001	3	15
STOMACH	Innate immune response-activating signaling pathway →	+0.078	+1.888	.002	.003	3	15
URINARY_TRACT	CD8-positive, alpha-beta T cell activation →	+0.136	+2.395	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of cytokine-mediated signaling pathway →	+0.078	+2.893	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of response to cytokine stimulus →	+0.079	+2.696	<.001	<.001	3	14
SOFT_TISSUE	Negative regulation of IP-10 production →	+1.243	+2.539	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,518 associations by consensus.

Defense response to virus by TRIM22 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →