TRIM21

Across TCGA pan-cancer cohorts, TRIM21 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRIM21 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TRIM21 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM21 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

COAD, GBM, and LSCC are the cancer types where TRIM21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.876	1.000	.015	78	view →
GBM	DFS	Quartile	All	0.596	0.954	<.001	19	view →
LSCC	OS	Quartile	II,III,IV	0.516	0.917	.008	11	view →
HNSC	DFS	Quartile	IV	0.860	0.569	.021	7	view →
LUAD	DFS	Median	III,IV	0.687	0.360	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRIM21–COAD (DFS)

Open the COAD breakdown →