TRIM21

Across TCGA patient cohorts, TRIM21 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM21-associated genes across cancer lineages are Notch1, YAP, and p62 Lck ligand. Each is linked with TRIM21 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM21-to-partner and partner-to-TRIM21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TRIM21-low versus TRIM21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM21→partner) and Y-score (partner→TRIM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.185	+1.700	.001	.044	3	3
SKCM	YAP →	+0.241	+2.459	.011	.020	3	2
UCEC	p62 Lck ligand →	+0.383	+3.169	.005	.018	3	2
UCEC	c-Met_pY1235 →	+0.062	+2.222	.048	.011	3	2
SKCM	HER3 →	+0.510	+2.321	.010	.033	3	1
UCEC	A-Raf_pS299 →	-0.142	-3.000	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Notch1 by TRIM21 expression — UCEC

Explore this box plot interactively →