TRIM21

Across TCGA cell cohorts, TRIM21 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TRIM21-associated genes across cancer lineages are SIGLEC7, MYF5, and IL17A. Each is linked with TRIM21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM21-to-partner and partner-to-TRIM21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC7 grouped by TRIM21-low versus TRIM21-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM21→partner) and Y-score (partner→TRIM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SIGLEC7 →	+0.063	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	MYF5 →	+0.663	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	IL17A →	+0.003	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	EPX →	+0.032	+3.607	.008	.006	3	1
LUNG_NSCLC_LUAD	OR8B12 →	+0.052	+4.149	<.001	<.001	3	1
LUNG_NSCLC_LUAD	TENT5D →	+0.078	+3.614	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SIGLEC7 by TRIM21 expression — OESOPHAGUS

Explore this box plot interactively →