TRIM21

Across TCGA cell cohorts, TRIM21 mutation is significantly associated with the mutation status of many other genes, with 1,945 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM21-associated genes across cancer lineages are MCTP2, TRIM2, and GRK3. Each is linked with TRIM21 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRIM21-to-partner and partner-to-TRIM21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCTP2 grouped by TRIM21-low versus TRIM21-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM21→partner) and Y-score (partner→TRIM21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MCTP2 →	+5.502	+5.502	.003	.003	1	4
OVARY	TRIM2 →	+4.415	+4.977	.007	.007	1	3
OVARY	GRK3 →	+5.415	+5.415	.004	.004	1	3
OVARY	PARP4 →	+5.415	+5.415	.004	.004	1	3
SOFT_TISSUE	MET →	+4.502	+5.066	.007	.007	1	3
BLOOD_Leukemia	MGAT5 →	+4.736	+5.560	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,945 associations by consensus.

MCTP2 by TRIM21 expression — SOFT_TISSUE

Explore this box plot interactively →