TRIM2

Across TCGA patient cohorts, TRIM2 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM2-associated genes across cancer lineages are MEK1, 4E-BP1, and p27_pT157. Each is linked with TRIM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM2-to-partner and partner-to-TRIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TRIM2-low versus TRIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM2→partner) and Y-score (partner→TRIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.340	+2.263	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.275	+2.736	<.001	<.001	3	3
SKCM	p27_pT157 →	+0.210	+3.076	<.001	.016	3	2
UCEC	14-3-3_beta →	-0.082	-1.689	.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.191	-1.263	.002	.014	3	2
UCEC	Notch1 →	+0.145	+1.898	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

MEK1 by TRIM2 expression — UCEC

Explore this box plot interactively →