TRIM2

Across TCGA cell cohorts, TRIM2 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM2-associated genes across cancer lineages are TAAR8, RSPH6A, and SLC5A5. Each is linked with TRIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM2-to-partner and partner-to-TRIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR8 grouped by TRIM2-low versus TRIM2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM2→partner) and Y-score (partner→TRIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TAAR8 →	+0.019	+5.662	<.001	.002	3	2
LARGE_INTESTINE	RSPH6A →	+0.098	+3.688	.004	.001	3	1
LARGE_INTESTINE	SLC5A5 →	+0.378	+3.558	<.001	.006	3	1
LARGE_INTESTINE	NT5C1A →	+0.027	+2.777	<.001	.004	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	TEX101 →	+0.151	+3.708	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

TAAR8 by TRIM2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →