TRIM2

Across TCGA cell cohorts, TRIM2 mutation is significantly associated with the mutation status of many other genes, with 3,584 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM2-associated genes across cancer lineages are MCTP2, GAB1, and SLC15A3. Each is linked with TRIM2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRIM2-to-partner and partner-to-TRIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCTP2 grouped by TRIM2-low versus TRIM2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM2→partner) and Y-score (partner→TRIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MCTP2 →	+4.772	+5.339	.004	.004	1	5
LUNG_NSCLC_LUAD	GAB1 →	+4.187	+5.000	.008	.008	1	4
BLOOD_Leukemia	SLC15A3 →	+4.285	+4.285	.001	.001	1	4
BLOOD_Leukemia	RPL22 →	+2.825	+3.847	.001	.001	1	4
BLOOD_Leukemia	MAP7D1 →	+2.870	+3.347	.009	.009	1	4
CNS	POU4F1 →	+6.044	+6.044	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,584 associations by consensus.

MCTP2 by TRIM2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →