TRIM17

Across TCGA patient cohorts, TRIM17 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM17-associated genes across cancer lineages are NF2, Bax, and Caspase-7-cleavedD198. Each is linked with TRIM17 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM17-to-partner and partner-to-TRIM17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by TRIM17-low versus TRIM17-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM17→partner) and Y-score (partner→TRIM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NF2 →	+0.317	+2.820	.002	.035	3	2
COAD	Bax →	+0.383	+2.815	.001	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.736	+2.815	<.001	.036	2	3
COAD	Cyclin-B1 →	+0.650	+2.815	.030	.036	3	2
COAD	FASN →	+0.523	+2.815	.014	.036	3	1
COAD	Myosin-IIa_pS1943 →	+0.398	+2.832	.039	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

NF2 by TRIM17 expression — COAD

Explore this box plot interactively →