TRIM17

Across TCGA cell cohorts, TRIM17 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM17-associated genes across cancer lineages are BMP15, NLRP8, and KRTAP2-1. Each is linked with TRIM17 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM17-to-partner and partner-to-TRIM17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP15 grouped by TRIM17-low versus TRIM17-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM17→partner) and Y-score (partner→TRIM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BMP15 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	NLRP8 →	+0.041	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP2-1 →	+0.040	+5.643	.002	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.313	+3.295	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	C8A →	+0.018	+2.777	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

BMP15 by TRIM17 expression — BLOOD_Lymphoma

Explore this box plot interactively →