Across TCGA patient cohorts, TRIM16 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM16-associated genes across cancer lineages are ERK2, MEK1, and Notch1. Each is linked with TRIM16 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM16-to-partner and partner-to-TRIM16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM16→partner) and Y-score (partner→TRIM16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.271	+3.000	.015	.037	2	2
UCEC	MEK1 →	+0.524	+3.000	.013	.036	3	1
UCEC	Notch1 →	+0.237	+3.009	.003	.019	3	1
UCEC	ATM →	-0.798	-3.000	.002	.037	3	1
UCEC	PCNA →	+0.292	+3.000	.019	.037	2	1
UCEC	Cyclin-E1 →	+0.536	+3.000	.033	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TRIM16 survival (RNA) · tumor vs normal (RNA) · all TRIM16 data types