Across TCGA patient cohorts, TRIM15 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM15-associated genes across cancer lineages are Annexin-1, Bak, and XRCC1. Each is linked with TRIM15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM15-to-partner and partner-to-TRIM15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM15→partner) and Y-score (partner→TRIM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.548	+2.189	.011	.034	3	2
UCEC	Bak →	+0.282	+3.459	.006	.005	3	2
SKCM	XRCC1 →	+0.169	+1.807	.019	.026	3	2
UCEC	FoxM1 →	+0.244	+3.000	.022	.001	3	1
UCEC	Gab2 →	+0.352	+1.807	.017	.027	3	1
UCEC	INPP4B →	-0.383	-2.584	.004	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

TRIM15 survival (RNA) · tumor vs normal (RNA) · all TRIM15 data types