Across TCGA cell cohorts, TRIM15 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM15-associated genes across cancer lineages are MMP27, KRTAP12-3, and IZUMO3. Each is linked with TRIM15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM15-to-partner and partner-to-TRIM15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM15→partner) and Y-score (partner→TRIM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.061	+4.539	<.001	.007	3	1
LUNG_NSCLC_LUAD	IZUMO3 →	+0.022	+4.947	.002	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LUNG_SCLC	PRAMEF27 →	+0.020	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

TRIM15 survival (RNA) · tumor vs normal (RNA) · all TRIM15 data types