TRIM14

Across TCGA patient cohorts, TRIM14 mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM14-associated genes across cancer lineages are MIR181B1, RNU6-249P, and RNU6-591P. Each is linked with TRIM14 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM14-to-partner and partner-to-TRIM14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR181B1 grouped by TRIM14-low versus TRIM14-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM14→partner) and Y-score (partner→TRIM14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR181B1 →	+0.412	+5.124	<.001	.008	3	2
BLCA	RNU6-249P →	+0.479	+4.369	<.001	.002	3	2
BLCA	RNU6-591P →	+0.278	+5.033	<.001	.003	3	2
UCEC	RNU6-1067P →	+0.605	+3.868	<.001	.001	3	2
BRCA	MTND3P12 →	+0.155	+6.162	.004	.002	3	1
BRCA	EEF1E1-BLOC1S5 →	+0.100	+5.259	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

MIR181B1 by TRIM14 expression — HNSC

Explore this box plot interactively →