TRIM14

Across TCGA cell cohorts, TRIM14 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,756 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TRIM14-associated GO terms across cancer lineages are Regulation of type I interferon-mediated signaling pathway, Negative regulation of viral transcription, and Negative regulation of type I interferon-mediated signaling pathway. Each is linked with TRIM14 in more than 13 cancer types. Because this analysis shows association rather than direction, both TRIM14-to-partner and partner-to-TRIM14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of type I interferon-mediated signaling pathway grouped by TRIM14-low versus TRIM14-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM14→partner) and Y-score (partner→TRIM14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of type I interferon-mediated signaling pathway →	+0.125	+0.982	<.001	<.001	3	14
LUNG_SCLC	Negative regulation of viral transcription →	+0.145	+1.796	<.001	<.001	3	14
CNS	Negative regulation of type I interferon-mediated signaling pathway →	+0.136	+0.933	<.001	<.001	3	13
OESOPHAGUS	Negative regulation of IP-10 production →	+1.308	+1.345	.001	<.001	3	13
KIDNEY	Negative regulation of viral process →	+0.188	+1.733	.001	<.001	3	12
OVARY	Regulation of interferon-beta production →	+0.055	+1.065	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,756 associations by consensus.

Regulation of type I interferon-mediated signaling pathway by TRIM14 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →