TRIM14

Across TCGA cell cohorts, TRIM14 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRIM14-associated genes across cancer lineages are ITIH6, CSMD2, and PZP. Each is linked with TRIM14 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM14-to-partner and partner-to-TRIM14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITIH6 grouped by TRIM14-low versus TRIM14-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM14→partner) and Y-score (partner→TRIM14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITIH6 →	+0.026	+3.754	<.001	.006	3	1
BLOOD_Leukemia	CSMD2 →	+0.905	+3.882	<.001	.003	3	1
BLOOD_Leukemia	PZP →	+0.125	+3.839	<.001	.003	3	1
BLOOD_Leukemia	OR11H1 →	+0.052	+4.201	<.001	.001	3	1
BLOOD_Leukemia	SLC17A4 →	+0.062	+3.567	<.001	.003	3	1
BLOOD_Leukemia	CLVS2 →	+1.380	+3.847	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ITIH6 by TRIM14 expression — BLOOD_Leukemia

Explore this box plot interactively →