TRIM14

Across TCGA cell cohorts, TRIM14 mutation is significantly associated with the mutation status of many other genes, with 2,603 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM14-associated genes across cancer lineages are EXPH5, SGSH, and VWDE. Each is linked with TRIM14 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM14-to-partner and partner-to-TRIM14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXPH5 grouped by TRIM14-low versus TRIM14-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM14→partner) and Y-score (partner→TRIM14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EXPH5 →	+2.825	+3.847	.001	.001	1	3
BLOOD_Leukemia	SGSH →	+3.285	+3.662	.004	.004	1	3
LARGE_INTESTINE	VWDE →	+2.215	+3.247	.003	.003	1	3
LARGE_INTESTINE	PATZ1 →	+3.799	+3.329	.005	.005	1	2
LARGE_INTESTINE	L3MBTL2 →	+5.536	+4.781	<.001	<.001	1	2
BLOOD_Leukemia	PAK5 →	+3.548	+3.845	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,603 associations by consensus.

EXPH5 by TRIM14 expression — BLOOD_Leukemia

Explore this box plot interactively →