TRIM11

Across TCGA pan-cancer cohorts, TRIM11 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TRIM11 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRIM11 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM11 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where TRIM11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.603	0.838	.002	30	view →
UCEC	DFS	Median	All	0.980	0.832	.004	14	view →
CCRCC	DFS	Quartile	II,III,IV	0.785	0.241	.031	4	view →
LUAD	DFS	Median	II,III,IV	0.796	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TRIM11–HNSC (OS)

Open the HNSC breakdown →