TRIM11

Across TCGA patient cohorts, TRIM11 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM11-associated genes across cancer lineages are ATM, 14-3-3_beta, and A-Raf_pS299. Each is linked with TRIM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM11-to-partner and partner-to-TRIM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TRIM11-low versus TRIM11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM11→partner) and Y-score (partner→TRIM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.633	-2.571	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.131	-2.780	<.001	.003	3	1
UCEC	A-Raf_pS299 →	-0.160	-1.700	<.001	.042	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.445	+1.678	.006	.023	3	1
UCEC	Heregulin →	-0.146	-3.446	.002	.005	3	1
UCEC	JNK2 →	+0.325	+3.710	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ATM by TRIM11 expression — UCEC

Explore this box plot interactively →