TRIM11

Across TCGA cell cohorts, TRIM11 mutation is significantly associated with the RNA expression of many other genes, with 341 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM11-associated genes across cancer lineages are KRTAP11-1, WFDC11, and OR8B4. Each is linked with TRIM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM11-to-partner and partner-to-TRIM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP11-1 grouped by TRIM11-low versus TRIM11-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM11→partner) and Y-score (partner→TRIM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP11-1 →	+0.026	+5.415	<.001	.004	3	2
SKIN	WFDC11 →	+0.100	+4.977	<.001	.007	3	1
SKIN	OR8B4 →	+0.032	+4.977	<.001	.007	3	1
LARGE_INTESTINE	FZD3 →	+0.791	+3.212	.003	.006	3	1
LARGE_INTESTINE	ASPN →	+0.040	+2.841	<.001	.002	3	1
LARGE_INTESTINE	RAD51C →	+0.846	+3.299	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 341 associations by consensus.

KRTAP11-1 by TRIM11 expression — SKIN

Explore this box plot interactively →