TRIM11

Across TCGA cell cohorts, TRIM11 mutation is significantly associated with the mutation status of many other genes, with 4,395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM11-associated genes across cancer lineages are MCM3AP, DACT2, and ADAMTS20. Each is linked with TRIM11 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM11-to-partner and partner-to-TRIM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM3AP grouped by TRIM11-low versus TRIM11-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM11→partner) and Y-score (partner→TRIM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MCM3AP →	+4.437	+5.000	.007	.007	1	3
BREAST	DACT2 →	+5.297	+5.297	.004	.004	1	3
BREAST	ADAMTS20 →	+4.297	+4.857	.009	.009	1	3
SKIN	AMER1 →	+4.239	+5.053	.007	.007	1	3
LARGE_INTESTINE	KANK2 →	+3.369	+3.000	<.001	<.001	1	3
LARGE_INTESTINE	SLC19A1 →	+2.632	+2.632	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,395 associations by consensus.

MCM3AP by TRIM11 expression — BONE

Explore this box plot interactively →