TRH

Across TCGA patient cohorts, TRH mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRH-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and MEK1. Each is linked with TRH in more than 1 cancer types. Because this analysis shows association rather than direction, both TRH-to-partner and partner-to-TRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TRH-low versus TRH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRH→partner) and Y-score (partner→TRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.411	+3.169	.036	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.217	-3.156	.019	.020	3	1
UCEC	MEK1 →	+0.600	+3.169	.002	.019	3	1
UCEC	p62 Lck ligand →	+0.375	+3.009	.036	.019	3	1
UCEC	AR →	-0.547	-3.169	.007	.020	3	1
UCEC	4E-BP1_pT70 →	+0.134	+3.169	.033	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

eEF2 by TRH expression — UCEC

Explore this box plot interactively →