TRH

Across TCGA cell cohorts, TRH RNA expression is significantly associated with the go_rna of many other GO terms, with 1,585 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TRH-associated GO terms across cancer lineages are RNA catabolic process, Establishment of vesicle localization, and Symbiont-mediated disruption of host cellular anatomical structure. Each is linked with TRH in more than 5 cancer types. Because this analysis shows association rather than direction, both TRH-to-partner and partner-to-TRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA catabolic process grouped by TRH-low versus TRH-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRH→partner) and Y-score (partner→TRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNA catabolic process →	+0.034	+0.062	.001	.004	3	6
BREAST	Establishment of vesicle localization →	+0.057	+0.525	<.001	.001	3	5
OESOPHAGUS	Symbiont-mediated disruption of host cellular anatomical structure →	+0.151	+0.033	.001	.004	2	6
OESOPHAGUS	Symbiont-mediated disruption of host anatomical structure →	+0.151	+0.033	.001	.004	2	6
LUNG_SCLC	Vesicle tethering →	+0.100	+0.816	<.001	<.001	3	5
LUNG_SCLC	Late viral transcription →	+0.097	+0.635	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,585 associations by consensus.

RNA catabolic process by TRH expression — LARGE_INTESTINE

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