TRGVB

Across TCGA pan-cancer cohorts, TRGVB RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRGVB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRGVB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRGVB is over-expressed in tumor.

KIRC, PRAD, and HNSC are the cancer types where TRGVB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRGVB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.085	.001	7	view →
PRAD	All	All	+1.499	<.001	2	view →
HNSC	All	II,III,IV	+0.014	.045	2	view →
KIRP	Female	All	+0.078	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TRGVB–KIRC

Open the KIRC breakdown →