Across TCGA pan-cancer cohorts, TRGVA RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRGVA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRGVA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRGVA is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where TRGVA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRGVA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.236	<.001	10	view →
LUAD	All	II,III,IV	−0.300	<.001	7	view →
LUSC	All	All	−0.255	<.001	5	view →
PRAD	All	All	+0.380	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRGVA RNA expression & survival · all TRGVA data types