Across TCGA pan-cancer cohorts, TRGV8 RNA is linked to patient survival in 2 of 34 cancer types, making it the most broadly survival-associated TRGV8 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TRGV8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRGV8 expression acts as an unfavorable survival marker.

LGG and SARC are the cancer types where TRGV8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Tertile	All	0.205	0.834	<.001	36	view →
SARC	DFS	Tertile	All	0.118	0.591	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TRGV8 tumor-vs-normal RNA expression · all TRGV8 data types