TRGV7

Across TCGA pan-cancer cohorts, TRGV7 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TRGV7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRGV7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRGV7 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where TRGV7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRGV7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.618	<.001	12	view →
COAD	Female	II,III,IV	−0.726	<.001	9	view →
LUAD	Female	III,IV	−1.317	<.001	8	view →
LUSC	Male	II,III,IV	−1.213	<.001	8	view →
KIRP	All	All	+0.639	<.001	4	view →
HNSC	All	II,III,IV	+0.305	.025	4	view →
CHOL	All	II,III,IV	−0.690	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TRGV7–KIRC

Open the KIRC breakdown →