TRGV2

Across TCGA patient cohorts, TRGV2 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible TRGV2-associated genes across cancer lineages are Eosinophils, Neutrophils, and Macrophages M1. Each is linked with TRGV2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRGV2-to-partner and partner-to-TRGV2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Eosinophils grouped by TRGV2-low versus TRGV2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRGV2→partner) and Y-score (partner→TRGV2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Eosinophils →	+0.031	+2.588	.001	.009	3	1
LUSC	Neutrophils →	+0.008	+2.206	.007	.024	3	1
UCEC	Macrophages M1 →	+0.019	+3.065	.041	.029	3	1
UCEC	pDC →	+0.064	+2.818	.030	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Eosinophils by TRGV2 expression — LUSC

Explore this box plot interactively →