Across TCGA pan-cancer cohorts, TRGV11 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TRGV11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRGV11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRGV11 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC and LUSC are the cancer types where TRGV11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRGV11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.026	.008	4	view →
LUSC	All	All	−0.032	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TRGV11 RNA expression & survival · all TRGV11 data types