Across TCGA patient cohorts, TRGC2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRGC2-associated genes across cancer lineages are Shc_pY317, c-Jun_pS73, and A-Raf_pS299. Each is linked with TRGC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRGC2-to-partner and partner-to-TRGC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRGC2→partner) and Y-score (partner→TRGC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Shc_pY317 →	+0.284	+2.853	.001	.034	3	1
LUSC	c-Jun_pS73 →	+0.263	+2.834	.008	.035	3	1
UCEC	A-Raf_pS299 →	-0.140	-3.000	.007	.036	3	1
UCEC	Heregulin →	-0.127	-2.308	.019	.033	3	1
UCEC	MEK1 →	+0.403	+2.807	.011	.003	3	1
UCEC	Myosin-IIa_pS1943 →	+0.269	+2.128	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

TRGC2 survival (RNA) · tumor vs normal (RNA) · all TRGC2 data types