Across TCGA patient cohorts, TREX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,641 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TREX2-associated proteins across cancer lineages are MSH6, NKRF, and ZMYM3. Each is linked with TREX2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TREX2-to-partner and partner-to-TREX2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX2→partner) and Y-score (partner→TREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	+0.367	+0.372	<.001	.006	3	4
LSCC	NKRF →	+0.325	+0.339	.004	.001	3	4
OV	ZMYM3 →	+0.306	+0.484	.002	<.001	2	5
LSCC	DNAJC2 →	+0.253	+0.342	.001	.001	3	4
HNSC	GAR1 →	+0.304	+0.765	.007	.004	3	4
LUAD	SMPD4 →	+0.198	+0.352	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,641 associations by consensus.

Exploration

TREX2 survival (RNA) · tumor vs normal (RNA) · all TREX2 data types