Across TCGA patient cohorts, TREX2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,017 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible TREX2-associated genes across cancer lineages are YPEL1, SLC35E4, and GRK3. Each is linked with TREX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREX2-to-partner and partner-to-TREX2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX2→partner) and Y-score (partner→TREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	YPEL1 →	-0.721	-1.349	<.001	<.001	3	1
HNSC	SLC35E4 →	+0.520	+1.551	<.001	<.001	3	1
HNSC	GRK3 →	-0.817	-1.083	.001	.002	3	1
HNSC	LGALS2 →	-1.065	-0.951	.001	.009	3	1
HNSC	CRYBB1 →	-0.394	-1.054	.003	.002	3	1
HNSC	TTC28 →	-0.968	-1.519	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,017 associations by consensus.

Exploration

TREX2 survival (RNA) · tumor vs normal (RNA) · all TREX2 data types