Across TCGA patient cohorts, TREX2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TREX2-associated genes across cancer lineages are JNK2, PDCD4, and Shc_pY317. Each is linked with TREX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREX2-to-partner and partner-to-TREX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX2→partner) and Y-score (partner→TREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.278	+2.834	.005	.034	3	1
UCEC	PDCD4 →	-0.495	-2.321	.036	.035	3	1
UCEC	Shc_pY317 →	-0.171	-2.321	.024	.035	3	1
UCEC	ATM →	-0.473	-2.321	.038	.035	3	1
UCEC	GATA6 →	-0.190	-3.162	.024	.019	2	1
UCEC	Caspase-8 →	-0.293	-3.459	.020	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TREX2 survival (RNA) · tumor vs normal (RNA) · all TREX2 data types