Across TCGA cell cohorts, TREX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,072 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TREX2-associated GO terms across cancer lineages are U2-type prespliceosome assembly, Positive regulation of telomerase RNA localization to Cajal body, and Positive regulation of DNA-templated DNA replication. Each is linked with TREX2 in more than 12 cancer types. Because this analysis shows association rather than direction, both TREX2-to-partner and partner-to-TREX2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX2→partner) and Y-score (partner→TREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	U2-type prespliceosome assembly →	+0.132	+0.544	<.001	.001	3	13
BONE	Positive regulation of telomerase RNA localization to Cajal body →	+0.135	+0.570	<.001	.003	3	13
BONE	Positive regulation of DNA-templated DNA replication →	+0.152	+0.482	<.001	.004	3	12
PANCREAS	Signal transduction in response to DNA damage →	+0.062	+0.512	<.001	<.001	3	12
BONE	Metaphase/anaphase transition of cell cycle →	+0.235	+0.634	<.001	<.001	3	11
OESOPHAGUS	Negative regulation of mRNA splicing, via spliceosome →	+0.101	+0.675	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,072 associations by consensus.

Exploration

TREX2 survival (RNA) · tumor vs normal (RNA) · all TREX2 data types