Across TCGA cell cohorts, TREX2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TREX2-associated genes across cancer lineages are SPHKAP, CNBD1, and OR2B3. Each is linked with TREX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREX2-to-partner and partner-to-TREX2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX2→partner) and Y-score (partner→TREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPHKAP →	+0.006	+5.415	.007	.004	3	1
LARGE_INTESTINE	CNBD1 →	+0.576	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR2B3 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	POTEB2 →	+0.012	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

TREX2 survival (RNA) · tumor vs normal (RNA) · all TREX2 data types