TREML2

Across TCGA patient cohorts, TREML2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TREML2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and FoxM1. Each is linked with TREML2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREML2-to-partner and partner-to-TREML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TREML2-low versus TREML2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREML2→partner) and Y-score (partner→TREML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.089	-2.973	.042	.035	3	1
UCEC	EGFR_pY1068 →	-0.359	-2.807	.001	.003	3	1
UCEC	FoxM1 →	+0.245	+2.115	.030	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-3.584	.008	.002	3	1
UCEC	JNK2 →	+0.226	+3.469	.009	.002	3	1
UCEC	Ku80 →	+0.227	+1.598	.028	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

14-3-3_beta by TREML2 expression — UCEC

Explore this box plot interactively →