TREML1

Across TCGA patient cohorts, TREML1 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TREML1-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and lymphatic Endothelial cells. Each is linked with TREML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREML1-to-partner and partner-to-TREML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by TREML1-low versus TREML1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREML1→partner) and Y-score (partner→TREML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.015	+3.260	.025	.002	3	1
UCEC	CD8+ Tcm →	+0.031	+3.350	.003	.001	3	1
UCEC	lymphatic Endothelial cells →	-0.026	-2.968	.046	.036	3	1
UCEC	CD4+ memory T-cells →	+0.023	+2.202	.016	.017	3	1
UCEC	Th2 cells →	+0.214	+2.815	.031	.036	2	1
UCEC	CD8+ naive T-cells →	+0.045	+3.212	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CD8+ T-cells by TREML1 expression — UCEC

Explore this box plot interactively →