TREML1

Across TCGA cell cohorts, TREML1 RNA expression is significantly associated with the go_rna of many other GO terms, with 769 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TREML1-associated GO terms across cancer lineages are Positive regulation of DNA-templated transcription, elongation, Negative regulation of DNA-templated transcription, elongation, and Negative regulation of transcription elongation by RNA polymerase II. Each is linked with TREML1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TREML1-to-partner and partner-to-TREML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-templated transcription, elongation grouped by TREML1-low versus TREML1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TREML1→partner) and Y-score (partner→TREML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of DNA-templated transcription, elongation →	+0.046	+0.030	.002	.003	3	5
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.106	+0.157	<.001	.005	3	5
BONE	Negative regulation of transcription elongation by RNA polymerase II →	+0.118	+0.130	<.001	.005	3	5
BONE	Positive regulation of translation →	+0.057	+0.125	<.001	.008	2	6
OVARY	Regulation of mRNA catabolic process →	+0.040	+0.088	<.001	.002	3	5
PANCREAS	Regulation of telomerase RNA localization to Cajal body →	+0.070	+0.034	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 769 associations by consensus.

Positive regulation of DNA-templated transcription, elongation by TREML1 expression — PANCREAS

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