TREML1

Across TCGA cell cohorts, TREML1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TREML1-associated genes across cancer lineages are TMCO5A, OR10G2, and ST8SIA3. Each is linked with TREML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREML1-to-partner and partner-to-TREML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by TREML1-low versus TREML1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREML1→partner) and Y-score (partner→TREML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.026	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR10G2 →	+0.074	+4.977	<.001	.007	3	1
CNS	ST8SIA3 →	+0.671	+4.472	<.001	.004	3	1
BREAST	MTRNR2L10 →	+0.012	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TMCO5A by TREML1 expression — LARGE_INTESTINE

Explore this box plot interactively →