TREM2

Across TCGA pan-cancer cohorts, TREM2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TREM2 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TREM2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TREM2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where TREM2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	1.000	0.481	.008	12	view →
CCRCC	OS	Median	III,IV	0.455	0.985	.029	5	view →
PDAC	OS	Quartile	II,III,IV	0.936	0.676	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TREM2–LUAD (OS)

Open the LUAD breakdown →