TREM2

Across TCGA patient cohorts, TREM2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TREM2-associated genes across cancer lineages are Ku80, MEK1, and MSH2. Each is linked with TREM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREM2-to-partner and partner-to-TREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TREM2-low versus TREM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREM2→partner) and Y-score (partner→TREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.233	+2.335	.017	.003	3	1
UCEC	MEK1 →	+0.366	+2.115	.015	.017	3	1
UCEC	MSH2 →	-0.284	-3.433	.002	.005	3	1
UCEC	Notch1 →	+0.242	+3.598	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.392	+2.321	.003	.006	3	1
UCEC	P-Cadherin →	-0.125	-2.574	.036	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Ku80 by TREM2 expression — UCEC

Explore this box plot interactively →