TREM2

Across TCGA cell cohorts, TREM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 834 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TREM2-associated GO terms across cancer lineages are Negative regulation of macrophage colony-stimulating factor signaling pathway, Extracellular matrix organization, and Extracellular structure organization. Each is linked with TREM2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TREM2-to-partner and partner-to-TREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macrophage colony-stimulating factor signaling pathway grouped by TREM2-low versus TREM2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TREM2→partner) and Y-score (partner→TREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of macrophage colony-stimulating factor signaling pathway →	-0.226	-1.088	<.001	<.001	3	6
KIDNEY	Extracellular matrix organization →	+0.154	+0.168	<.001	.002	3	4
KIDNEY	Extracellular structure organization →	+0.154	+0.168	<.001	.002	3	4
KIDNEY	External encapsulating structure organization →	+0.154	+0.168	<.001	.002	3	4
KIDNEY	Regulation of postsynaptic membrane neurotransmitter receptor levels →	-0.078	-0.115	<.001	.003	3	4
BLOOD_Leukemia	Regulation of neuronal action potential →	-0.204	-0.591	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 834 associations by consensus.

Negative regulation of macrophage colony-stimulating factor signaling pathway by TREM2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →