TREM2

Across TCGA cell cohorts, TREM2 mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TREM2-associated genes across cancer lineages are DPRX. Each is linked with TREM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREM2-to-partner and partner-to-TREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by TREM2-low versus TREM2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREM2→partner) and Y-score (partner→TREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DPRX →	+0.057	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

DPRX by TREM2 expression — BLOOD_Lymphoma

Explore this box plot interactively →