TREM1

Across TCGA patient cohorts, TREM1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TREM1-associated genes across cancer lineages are Akt, GAPDH, and MSH2. Each is linked with TREM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREM1-to-partner and partner-to-TREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by TREM1-low versus TREM1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREM1→partner) and Y-score (partner→TREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Akt →	+0.405	+3.321	.010	.010	3	1
UCEC	GAPDH →	+0.589	+3.169	.018	.019	3	1
UCEC	MSH2 →	-0.249	-3.143	.020	.018	3	1
UCEC	p70-S6K →	+0.179	+1.901	.046	.031	3	1
UCEC	PDCD4 →	-0.526	-2.584	.016	.011	3	1
UCEC	STAT3_pY705 →	-0.470	-2.584	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Akt by TREM1 expression — SKCM

Explore this box plot interactively →