TREM1

Across TCGA cell cohorts, TREM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,128 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TREM1-associated GO terms across cancer lineages are Neutrophil-mediated killing of gram-negative bacterium, Establishment of protein localization to endoplasmic reticulum, and Response to endoplasmic reticulum stress. Each is linked with TREM1 in more than 11 cancer types. Because this analysis shows association rather than direction, both TREM1-to-partner and partner-to-TREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophil-mediated killing of gram-negative bacterium grouped by TREM1-low versus TREM1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TREM1→partner) and Y-score (partner→TREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Neutrophil-mediated killing of gram-negative bacterium →	+1.225	+1.017	<.001	<.001	3	12
SOFT_TISSUE	Establishment of protein localization to endoplasmic reticulum →	+0.110	+0.865	<.001	<.001	3	9
SOFT_TISSUE	Response to endoplasmic reticulum stress →	+0.041	+0.537	<.001	<.001	3	8
SOFT_TISSUE	Protein targeting to ER →	+0.107	+0.635	<.001	.001	3	8
BREAST	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.080	+0.545	.007	.008	3	8
SOFT_TISSUE	Endoplasmic reticulum to cytosol transport →	+0.102	+0.896	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,128 associations by consensus.

Neutrophil-mediated killing of gram-negative bacterium by TREM1 expression — BLOOD_Leukemia

Explore this box plot interactively →