TREH

Across TCGA patient cohorts, TREH mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TREH-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and EGFR. Each is linked with TREH in more than 1 cancer types. Because this analysis shows association rather than direction, both TREH-to-partner and partner-to-TREH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TREH-low versus TREH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREH→partner) and Y-score (partner→TREH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.743	+2.906	.001	.001	3	2
UCEC	14-3-3_beta →	-0.116	-2.209	.006	.011	3	1
UCEC	EGFR →	-0.181	-2.906	.007	.001	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.408	+1.700	.024	.044	3	1
UCEC	INPP4B →	-0.381	-3.321	.005	.009	3	1
UCEC	MEK1 →	+0.329	+1.700	.034	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Cyclin-B1 by TREH expression — UCEC

Explore this box plot interactively →