Across TCGA patient cohorts, TRDN mutation is significantly associated with the RNA expression of many other genes, with 2,248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRDN-associated genes across cancer lineages are RN7SKP252, MPV17L, and NDUFAF2. Each is linked with TRDN in more than 3 cancer types. Because this analysis shows association rather than direction, both TRDN-to-partner and partner-to-TRDN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRDN→partner) and Y-score (partner→TRDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP252 →	+0.108	+5.147	<.001	.003	3	4
UCEC	MPV17L →	-0.710	-1.847	<.001	<.001	3	3
UCEC	NDUFAF2 →	+0.557	+1.857	<.001	<.001	3	3
LUAD	OR7E10P →	+0.049	+4.888	<.001	.005	3	3
UCEC	PSMD9 →	+0.348	+2.099	<.001	<.001	3	3
UCEC	RRAGC →	+0.288	+1.486	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,248 associations by consensus.

Exploration

TRDN survival (RNA) · tumor vs normal (RNA) · all TRDN data types